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One recent research from Yale University found that vanillin — an extract of the vanilla bean — transforms into chemical substances known as acetals when aerosolized. Those chemicals, the researchers stated, could additionally be particularly irritating to the lungs and trigger damage when inhaled. Studies have shown that inhaling aerosolized propylene glycol might contribute to bronchial asthma. And a 2012 case report concerned a lady who developed a situation called exogenous lipoid pneumonia after vaping for about six months.

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